Webvision: The Organization of the Retina and Visual System 2008 In: Kolb H, Fernandez E, Nelson R, editors. Melanopsin-expressing, Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs). Melatonin feedback on clock genes: a theory involving the proteasome. Neurotransmitters of the suprachiasmatic nuclei. Neurotransmitters of the retino-hypothalamic tract. Characterization of the suprachiasmatic nucleus in organotypic slice explant cultures. A diurnal variation of vasoactive intestinal peptide (VIP) mRNA under a daily light-dark cycle in the rat suprachiasmatic nucleus. Okamoto S, Okamura H, Miyake M, Takahashi Y, Takagi S, Akagi K, et al. Clock Genes and Altered Sleep–Wake Rhythms: Their role in the development of psychiatric disorders. 2008 Jun 58(1):18-47.Ĭharrier A, Olliac B, Roubertoux P, Tordjman S. Organization of cell and tissue circadian pacemakers: a comparison among species. Amplitude of the SCN clock enhanced by the behavioral activity rhythm. Van Oosterhout F, Lucassen EA, Houben T, vanderLeest HT, Antle MC, Meijer JH. The 24-hour scale: a time dimension of adaptive functional organization. Night and Shift Work and Transmeridian and Space Flights, 243-255, 1992. Eyeless Mexican cavefish save energy by eliminating the circadian rhythm in metabolism. The Suprachiasmatic Nucleus and the Circadian Timekeeping System of the Body. From Linnaean Species to Mendelian Factors: Elements of Hybridism, 1751–1870.
The background of linnaeus’s contributions to the nomenclature and methods of systematic biology. Biological Rhythms in Human and Animal Physiology By G.G. Studies in Biology 6, E.Arnold Publ, London:49, 1967. Epidemiology of the human circadian clock. Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, et al. Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. endogeni časovnik, pineala žlezda, melatonin Svetlost, pinealna žlezda i melatonin regulišu ciklus spavanja i svako narušavanje dovodi do disfunkcija. Koncentracija melatonina u krvi je odsutna ili nemerljiva tokom dana. Pinealna žlezda je u direktnoj vezi sa endogenim satom i luči hormon melatonin koji proizvodi pospanost. To je način na koji se prilagođavaju fiziološke funkcije različitim fazama dana, povećavaju aktivnost neurona u suprahijazmatskom jedru (SCN) koji regulišu budnost/STS i kontrolišu endogeni časovnik. Sa izvrsnom preciznošću naš unutrašnji sat reguliše kritične funkcije kao što su ponašanje, nivo hormona, spavanje, temperaturu tela, metabolizam i dr. Za ovo otkriče Američki naučnici su dobili Nobelovu nagradu za fiziologiju ili medicinu za 2017 god. Ovi proteini se akumuliraju u ćeliji tokom noći i degradiraju tokom dana, osciluju tokom 24-časovnog ciklusa, sinhrono sa cirkadijalnim ritmom. Pronađeni su geni per i tim (per/tim/tau dbt) koji kodiraju proteine: per (periodic) i tim (timeless). Generisanje cirkadijalnog oscilatora je bazirano na isprepletanim negativnim povratnim spregama, ekspresiji gena za vreme (eng. Sve eukariote pokazuju promenu u ispoljavanju genskih (ritam sinteze DNA i RNA, ritam mitoza), biohemijskih (metabolički ritmovi) i fizioloških (ritam sinteze i sekrecije endokrinih hormona, menstrualni ciklus žene, ritmične promene temperature, otkucaji srca, frekvencija disanja ciklus budnost i spavanje, rad i odmor i dr) aktivnosti pojačavajući i smanjujući svoje delovanje kroz cikluse. It does not store any personal data.Pojave koje se u živom svetu ponavljaju istim redom i u istim vremenskim intervalima nazivaju se biološkim ritmovima. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics".
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